Preheat oven to 350 degrees. Line a baking sheet with parchment paper.
In a large bowl, toss the cauliflower with the avocado oil, smoked paprika, salt, and pepper. Arrange the florets in a single layer and bake for 18 minutes.
While the cauliflower is baking, bring the cream to a simmer over medium heat. Add the cream cheese and buffalo sauce. Cook, stirring often, until the cream cheese melts.
Reduce heat to low and stir 1 cup of cheddar cheese, 1 cup of blue cheese, garlic powder, salt, black pepper, and cayenne pepper. Cook until the cheese melts.
Toss the sauce with the chicken and cauliflower and transfer to a 9 x 9 casserole dish. Top with remaining cheddar and blue cheese.
Bake for 20 minutes.