4-Cheese Spinach Artichoke Chicken Casserole (Keto, Low-Carb)

Need dinner to just handle itself for once? This Spinach Artichoke Chicken Casserole comes together fast—just 15 minutes of prep, then straight into the oven. It’s creamy, cheesy, full of flavor, and just the kind of baked chicken dish that works for both busy weeknights and make-ahead freezer meals. No overthinking, no extra mess—just comfort in a casserole dish.

Ingredients for Making Chicken Artichoke Casserole

• Heavy Cream: You want to use full-fat heavy cream. Half and half works if you are not keto.
• Chicken Broth: I like to use homemade chicken broth because it adds more flavor. You can also use water if you are watching your sodium intake.
• Butter: You can use salted or unsalted butter.
• Cream Cheese: I recommend using full-fat cream cheese for this recipe to keep it low-carb. However, you could use low-fat if you aren't keto wanted to reduce the calories.
• Garlic Powder: This is a great way to add flavor without chopping fresh garlic.
• Salt: I like to use sea salt, but you can use any type of salt that you have on hand.
• Pepper: I recommend using freshly ground black pepper for this recipe.
• Spinach: I used frozen spinach for this recipe because it is more convenient. You could use fresh spinach, but you must cook it down in a large skillet before adding it to the casserole.
• Artichoke Hearts: I like to use canned artichoke hearts because they are already cooked and ready to use. You can find them in the canned vegetable aisle at your grocery store. Use water-packed to avoid too much oil in your casserole.
• Chicken: I used cooked and cubed chicken breast for this recipe, but you could also use rotisserie chicken or shredded chicken.
• Mozzarella Cheese: I used mozzarella cheese because it melts well, but you could also use cheddar cheese if you prefer.
• Parmesan Cheese: I like to grate my parmesan cheese for the most flavor.
• Feta Cheese: I used crumbled feta cheese, but you could also use goat cheese in this chicken artichoke spinach casserole if you prefer.

Tools Needed to Make Chicken Artichoke Bake

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• 8 x 8 casserole dish
• Large Saucepan

How to Make Spinach Artichoke Chicken Casserole

First, start by preheating your oven to 350° F. Then, spray an 8 x 8 casserole dish with cooking spray and set it aside.

Next, you will need to heat the cream, chicken broth, and butter in a large saucepan over medium heat until the butter melts.

Once the butter has melted, add the cream cheese, garlic powder, salt, and pepper. Whisk until the cream cheese melts, which should take about 5 to 7 minutes.

Then, stir in the spinach, artichokes, and chicken. Transfer the mixture to the prepared casserole dish.

Finally, top with mozzarella cheese, parmesan cheese, and feta cheese. Cook for 20 minutes until the cheese is melted and bubbly.

Season to taste with salt and pepper.

Enjoy!

I hope you enjoy this Spinach Artichoke Chicken Casserole as much as we do! If you try it, please leave me a comment and let me know how you liked it.